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MT2 (Melanotan II): The Advanced Melanocortin Peptide for Pigmentation & Receptor Research

Buy MT2 (Melanotan II) Peptide EU & UK, eupeptidelap.co.uk is proud to present MT2 (Melanotan II) , a premium research-grade cyclic heptapeptide manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with Melanotan II for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in melanogenesis, melanocortin receptor pharmacology, and pigmentation biology. Buy MT2 (Melanotan II) Peptide EU & UK

Melanotan II (MT2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), originally developed at the University of Arizona in the 1980s to increase melanin formation and protect the skin from harmful UV radiation . The peptide has the cyclic structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH2, with the crucial D-Phe-7 substitution that contributes to its superagonist properties and enhanced potency compared to earlier melanotropic peptides. Buy MT2 (Melanotan II) Peptide EU & UK

The molecular formula of MT2 is C₅₀H₆₉N₁₅O₉, with a molecular weight of approximately 1024 Da . Its cyclic structure, stabilized by a lactam bridge, confers significant stability and enhanced receptor binding affinity compared to linear α-MSH analogs . This structural design enables prolonged biological activity and improved potency at melanocortin receptors .

MT2 acts as a non-selective agonist of melanocortin receptors, binding to MC1R (primarily responsible for melanogenesis), MC3R, and MC4R . Its propensity to improve skin pigmentation has made it a valuable research tool for melanogenesis studies, while its modulation of other melanocortin receptors opens doors for investigations into sexual function and appetite regulation . This “pharmacologically noisy” molecule delivers potent effects across multiple receptor subtypes, making it a complex but valuable tool for receptor pharmacology research .

For researchers seeking to buy peptide online EU for investigations into melanocortin receptor signaling, melanogenesis pathways, or sexual function mechanisms, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of MT2 (Melanotan II) Research

Discovery and Development

Melanotan II was created as a counterpart to the body’s naturally occurring hormone, alpha-melanocyte-stimulating hormone (α-MSH), and was designed to enhance the body’s natural tanning process by activating melanocortin receptors . Early research focused on its capacity to increase melanin formation and provide protection against sun-induced skin damage . However, during clinical investigations, researchers discovered that Melanotan II affected other physiological functions beyond pigmentation, including appetite regulation and sexual arousal, leading to potential applications in obesity and erectile dysfunction research .

Mechanism of Action: Melanocortin Receptor Activation

MT2 works by mimicking the effects of α-MSH on the melanocortin receptor system, which comprises five receptor subtypes (MC1R to MC5R) that control a range of physiological functions including pigmentation, appetite, and sexual function .

MC1R Activation and Melanogenesis: Of these receptors, MC1R is principally responsible for regulating melanogenesis—the process that produces skin pigmentation. When MT2 binds to MC1R on melanocytes, it triggers a signaling cascade that pushes the melanocyte toward producing more eumelanin (brown-black pigment) over pheomelanin (red-yellow pigment) and increases overall melanin content . This results in a darker, more UV-resistant skin phenotype over time—similar to how some individuals naturally tan more deeply due to their MC1R variants, but induced pharmacologically .

MC3R and MC4R Activation: MT2’s broader receptor affinity extends its pharmacology well beyond the skin. By acting on MC3R and MC4R in the central nervous system, it modulates appetite, energy homeostasis, and sexual function . This explains why researchers observe effects such as appetite suppression, changes in libido, and erectile responses in experimental models . The cyclic design of MT2 improves stability and potency, so lower doses still exert strong effects across multiple receptor systems .

Pharmacokinetic Profile

MT2 is typically administered subcutaneously in research models, where it is absorbed into the bloodstream, distributed through the body, and then cleared by enzymatic degradation and renal excretion . Available data from early-stage studies suggest a plasma half-life on the order of about 30 minutes to a couple of hours, with many sources clustering around approximately 1 hour . This short plasma half-life is typical for unmodified peptides that are not pegylated, lipidated, or otherwise engineered for extended circulation.

However, a short plasma half-life does not mean a short functional effect. Once MT2 binds melanocortin receptors in melanocytes and downstream signaling initiates, the biological cascade—upregulated melanin synthesis, packaging in melanosomes, and transfer to keratinocytes—continues well after the peptide level falls . This explains why a brief spike in blood levels can translate into pigmentation effects over several days or weeks.

Key Research Applications

Melanogenesis and Pigmentation Research

MT2 is extensively used in studies investigating skin pigmentation mechanisms and melanin synthesis pathways. Early Phase I clinical studies demonstrated that subcutaneous injections of MT2 produced increased pigmentation in the face, upper body, and buttock, as measured by quantitative reflectance and visual perception just one week after dosing ended . These results confirmed that MT2 has tanning activity in humans given only 5 low doses every other day by subcutaneous injection .

Research has shown that MT2 can induce significant changes in skin color in vivo, such as transforming the pelage color of mice from light yellow to dark brown or black upon subcutaneous administration, demonstrating its potent melanogenic efficacy . The peptide also enhances tyrosinase activity—a key enzyme in melanin synthesis—for days after initial exposure, suggesting a lasting effect at the transcriptional or translational level .

Sexual Function and Libido Research

During early clinical trials, researchers observed a notable effect on sexual function. A stretching and yawning complex appeared to correlate with the onset of spontaneous, penile erections which were intermittently experienced for 1–5 hours after MT2 dosing, depending on the dose administered . This finding prompted research into the possibility of using MT2 to study sexual dysfunction, particularly erectile dysfunction, where it could offer an alternative to conventional treatments .

The recommended single MT2 dose for erectile dysfunction research, based on Phase I studies, is 0.025 mg/kg/day . Studies on how MT2 affects sexual function have revealed that it may heighten sexual desire and improve overall sexual satisfaction, making it relevant for broader research into sexual health and dysfunction .

Appetite Regulation and Obesity Research

MT2’s role in regulating appetite and energy balance represents another intriguing research application. By acting on MC4R to regulate energy balance and decrease food intake, MT2 has potential as a research tool for studying obesity and metabolic disorders . The peptide’s ability to affect hunger presents a novel avenue for investigating metabolic pathways and potential therapeutic interventions .

Photoprotection and Skin Cancer Research

MT2 was initially investigated for its potential to prevent skin cancer by increasing melanin formation and providing protection against damaging UV radiation . This is especially relevant for fair-skinned individuals who are more susceptible to melanoma. By boosting the body’s natural defenses against UV radiation through increased melanin production, MT2 may help reduce the chance of sunburn and subsequent skin damage . Research in this area continues to explore the peptide’s potential role in photoprotection strategies .

Melanocortin Receptor Pharmacology

MT2 serves as a valuable research tool for studying melanocortin receptor pharmacology and signaling pathways. Its non-selective agonist activity across MC1R, MC3R, and MC4R allows researchers to investigate receptor interactions, signal transduction mechanisms, and downstream effects in various tissue types .

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources MT2 (Melanotan II) from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	MT2 (Melanotan II, Melanotan-2)
CAS Number	121062-08-6
Molecular Formula	C₅₀H₆₉N₁₅O₉
Molecular Weight	~1024 Da
Sequence	Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH₂
Structure	Cyclic heptapeptide with lactam bridge
Purity	≥99% (HPLC verified)
Appearance	White to off-white lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in sterile water, bacteriostatic water, or PBS
Target Receptors	MC1R, MC3R, MC4R (melanocortin receptors)
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from date of manufacture (lyophilized)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized MT2 powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile bacteriostatic water or appropriate buffer according to research protocol
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: Store reconstituted MT2 at 2-8°C for short-term use. For longer-term storage, aliquot into single-use portions and store at -20°C . Avoid repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity with lot-specific COAs
Well-Characterized Cyclic Peptide: Extensively studied with over three decades of research
Potent MC1R Agonist: Stimulates melanogenesis and eumelanin production in melanocytes
MC3R/MC4R Activity: Modulates appetite, energy homeostasis, and sexual function
Enhanced Stability: Cyclic lactam bridge structure confers stability and potency
Melanogenesis Research: Investigate melanin synthesis pathways and pigmentation mechanisms
Sexual Function Studies: Research erectile function and libido modulation
Appetite Regulation: Study MC4R-mediated effects on food intake and energy balance
Obesity Research: Investigate metabolic pathways and weight regulation
Photoprotection Studies: Research UV protection and skin cancer prevention mechanisms
Receptor Pharmacology: Valuable tool for melanocortin receptor signaling studies
Well-Characterized Safety Profile: Phase I clinical studies conducted in humans
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is MT2 (Melanotan II) and how does it work?

A: MT2 (Melanotan II) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) that acts as a non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R) . It stimulates melanogenesis through MC1R activation, leading to increased eumelanin production, and modulates appetite and sexual function through MC3R and MC4R activation .

Q: What purity level can I expect when I buy MT2 from eupeptidelap.co.uk?

A: All MT2 (Melanotan II) from eupeptidelap.co.uk is tested to ≥99% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications.

Q: What is the molecular weight and CAS number of MT2?

A: MT2 has a molecular weight of approximately 1024 Da and CAS number 121062-08-6 . Its molecular formula is C₅₀H₆₉N₁₅O₉ and its structure is a cyclic heptapeptide with a lactam bridge .

Q: How should I store MT2 for long-term stability?

A: Store lyophilized MT2 powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. For short-term use, store reconstituted solution at 2-8°C; for longer-term storage, aliquot and store at -20°C .

Q: What is the solubility of MT2?

A: MT2 is soluble in sterile water, bacteriostatic water, or PBS . Reconstitute according to research protocol to achieve desired concentration.

Q: What research areas commonly use MT2?

A: MT2 is widely used in melanogenesis and pigmentation research, sexual function and libido studies, appetite regulation and obesity research, photoprotection and skin cancer research, and melanocortin receptor pharmacology studies .

Q: What is the mechanism of action of MT2?

A: MT2 binds to melanocortin receptors (MC1R, MC3R, MC4R), activating G protein-coupled receptor signaling pathways that increase cAMP and activate downstream effectors . MC1R activation stimulates melanogenesis, while MC3R/MC4R activation modulates appetite and sexual function .

Q: Do you ship MT2 to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship MT2 (Melanotan II) to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with MT2 orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Do you offer bulk quantities of MT2 for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

Advance Your Research with MT2 (Melanotan II)

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Whether you are exploring melanin synthesis pathways, designing sexual function studies, investigating appetite regulation mechanisms, or researching photoprotection strategies, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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MT2 (Melanotan II) Peptide