High-Purity SS-31 (Elamipretide) Research Peptide for Sale | 10mg Lyophilized Powder | ≥99% Purity | 48-Hour Delivery Across EU & UK

SS-31 Peptide (Elamipretide): The Advanced Mitochondrial-Targeted Peptide for Bioenergetics Research

Buy SS-31 Peptide EU & UK, eupeptidelap.co.uk is proud to present SS-31 Peptide (also known as Elamipretide), a premium research-grade mitochondrial-targeted peptide manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with SS-31 for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in mitochondrial function, oxidative stress, and cellular bioenergetics. Buy SS-31 Peptide EU & UK

SS-31 (D-Arg-Dmt-Lys-Phe-NH₂) is a novel, synthetically produced tetrapeptide that targets the inner mitochondrial membrane with remarkable specificity . Developed by researchers at Cornell University and the National Institutes of Health, SS-31 was designed to selectively interact with cardiolipin, a unique phospholipid found exclusively in the inner mitochondrial membrane that is critical for maintaining mitochondrial architecture and function. Buy SS-31 Peptide EU & UK

The amino acid sequence of SS-31 is D-Arg-2′,6′-dimethyltyrosine-Lys-Phe-NH₂, with a molecular weight of approximately 639.8 g/mol . The peptide incorporates a dimethyltyrosine (Dmt) residue that confers antioxidant properties, and the use of D-amino acids enhances stability against proteolytic degradation . This unique structure allows SS-31 to concentrate in mitochondria with a thousand-fold higher accumulation compared to the cytoplasm, enabling it to protect mitochondria from oxidative damage at the site where reactive oxygen species (ROS) are generated .

SS-31 binds with high affinity to cardiolipin, the signature phospholipid of the inner mitochondrial membrane that maintains the structural integrity of the electron transport chain complexes . Through this mechanism, SS-31 protects mitochondrial cristae structure, enhances electron transport chain efficiency, reduces ROS production, and preserves ATP synthesis capacity .

For researchers seeking to buy peptide online EU for investigations into mitochondrial dysfunction, age-related decline, metabolic disorders, or neurodegenerative diseases, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of SS-31 Peptide Research

Discovery and Development

SS-31 (Elamipretide) was developed through a rational drug design approach targeting the mitochondrial inner membrane . The peptide belongs to a class of compounds known as Szeto-Schiller (SS) peptides, named after the researchers who pioneered their development . SS-31 is the lead compound in this class, demonstrating the most favorable pharmacological properties .

Mechanism of Action: Cardiolipin Targeting and Mitochondrial Stabilization

SS-31 exerts its effects through a unique mechanism involving selective targeting of cardiolipin, the signature phospholipid of the inner mitochondrial membrane .

Cardiolipin Binding: Cardiolipin is a unique dimeric phospholipid found exclusively in the inner mitochondrial membrane that is essential for maintaining the structural integrity of the electron transport chain . SS-31 binds to cardiolipin with high affinity, protecting it from oxidative damage .

Stabilization of Mitochondrial Architecture: By binding to cardiolipin, SS-31 preserves the organization of mitochondrial cristae and prevents the disassembly of electron transport chain supercomplexes . This stabilization is critical for maintaining efficient oxidative phosphorylation .

Reduction of ROS Production: Oxidized cardiolipin can dissociate from electron transport chain complexes, leading to increased ROS generation and further mitochondrial damage . SS-31 protects cardiolipin from oxidation, thereby reducing ROS production at its source .

Restoration of ATP Synthesis: By preserving electron transport chain integrity, SS-31 restores ATP synthesis capacity in mitochondria that have been compromised by oxidative stress or disease .

Selectivity and Distribution

SS-31 demonstrates remarkable selectivity for mitochondria, with a thousand-fold higher accumulation in mitochondria compared to the cytoplasm . This selectivity is achieved through a combination of electrostatic interactions with the mitochondrial membrane potential and specific binding to cardiolipin .

Key Research Applications

Mitochondrial Dysfunction Research

SS-31 is extensively used in studies investigating mitochondrial dysfunction across a wide range of pathological conditions:

Cardiolipin Oxidation: Study the role of cardiolipin in mitochondrial health and disease
Electron Transport Chain Integrity: Investigate the organization and stability of respiratory chain supercomplexes
Mitochondrial Bioenergetics: Measure oxygen consumption, ATP production, and membrane potential
Mitochondrial Dynamics: Explore effects on fusion, fission, and mitophagy

Aging Research

Age-related mitochondrial decline is a hallmark of cellular aging, and SS-31 has been studied extensively in aging models:

Age-Related Mitochondrial Decline: Investigate interventions that preserve mitochondrial function with age
Oxidative Stress: Study the accumulation of oxidative damage in aging mitochondria
Sarcopenia: Research preservation of muscle mitochondrial function in aging

Neurodegenerative Disease Research

SS-31 has been studied in models of various neurodegenerative diseases:

Alzheimer’s Disease: Investigate mitochondrial dysfunction in AD models
Parkinson’s Disease: Study protection of dopaminergic neurons against mitochondrial toxins
Huntington’s Disease: Explore mitochondrial bioenergetics in HD models

Cardiovascular Research

Cardiac tissue has high energy demands, making it particularly vulnerable to mitochondrial dysfunction:

Myocardial Ischemia-Reperfusion Injury: Study protection against ischemia-reperfusion damage
Heart Failure: Investigate mitochondrial bioenergetics in failing hearts
Cardiomyopathy: Explore mitochondrial contributions to cardiac pathology

Metabolic Disease Research

Mitochondrial dysfunction is a key feature of metabolic disorders:

Type 2 Diabetes: Study insulin resistance and mitochondrial function
Obesity: Investigate adipose tissue mitochondrial bioenergetics
Non-Alcoholic Fatty Liver Disease (NAFLD): Explore hepatic mitochondrial function

Kidney Disease Research

The kidney has high mitochondrial density and is vulnerable to oxidative damage:

Acute Kidney Injury: Study protection against ischemia-reperfusion and toxin-induced injury
Diabetic Nephropathy: Investigate mitochondrial contributions to diabetic kidney disease

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources SS-31 Peptide from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation (639.8 g/mol) via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	SS-31 Peptide (Elamipretide, D-Arg-Dmt-Lys-Phe-NH₂)
CAS Number	736992-21-5
Molecular Formula	C₃₂H₄₉N₉O₅
Molecular Weight	639.8 g/mol
Amino Acid Sequence	D-Arg-2′,6′-dimethyltyrosine-Lys-Phe-NH₂
Purity	≥99% (HPLC verified)
Appearance	White to off-white lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in sterile water, PBS, and aqueous buffers (≥10 mg/mL)
Target	Cardiolipin (inner mitochondrial membrane)
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from date of manufacture (lyophilized)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized SS-31 powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using sterile water, PBS, or bacteriostatic water according to research protocol
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: For short-term use, store at 2-8°C. For longer-term storage, aliquot into single-use portions and store at -20°C . Avoid repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity with lot-specific COAs
Mitochondrial-Targeted: Thousand-fold higher accumulation in mitochondria compared to cytoplasm
Cardiolipin Binding: Selectively binds to cardiolipin, the signature phospholipid of the inner mitochondrial membrane
Mitochondrial Stabilization: Preserves cristae structure and electron transport chain supercomplexes
ROS Reduction: Protects cardiolipin from oxidation, reducing ROS production at the source
ATP Preservation: Restores ATP synthesis capacity in compromised mitochondria
Aging Research: Studied extensively in age-related mitochondrial decline models
Neurodegenerative Disease: Investigated in Alzheimer’s, Parkinson’s, and Huntington’s disease models
Cardiovascular Research: Protects against ischemia-reperfusion injury and heart failure
Metabolic Disease: Studied in diabetes, obesity, and NAFLD models
Kidney Protection: Investigated in acute kidney injury and diabetic nephropathy
Enhanced Stability: D-amino acid configuration confers resistance to proteolytic degradation
Well-Characterized: Extensively studied with over 200 published papers
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is SS-31 and how does it work?

A: SS-31 (Elamipretide) is a mitochondrial-targeted tetrapeptide that selectively binds to cardiolipin, the signature phospholipid of the inner mitochondrial membrane . By protecting cardiolipin from oxidation, SS-31 preserves mitochondrial cristae structure, stabilizes electron transport chain complexes, reduces ROS production, and restores ATP synthesis .

Q: What purity level can I expect when I buy SS-31 from eupeptidelap.co.uk?

A: All SS-31 Peptide from eupeptidelap.co.uk is tested to ≥99% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications.

Q: What is the molecular weight and CAS number of SS-31?

A: SS-31 has a molecular weight of 639.8 g/mol and CAS number 736992-21-5 . Its molecular formula is C₃₂H₄₉N₉O₅ and amino acid sequence D-Arg-Dmt-Lys-Phe-NH₂ .

Q: How should I store SS-31 for long-term stability?

A: Store lyophilized SS-31 powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. For short-term use, store reconstituted solution at 2-8°C; for longer-term storage, aliquot and store at -20°C .

Q: What is the solubility of SS-31?

A: SS-31 is soluble in sterile water, PBS, and aqueous buffers at concentrations ≥10 mg/mL . It can be reconstituted with sterile water, bacteriostatic water, or PBS according to research protocol .

Q: What research areas commonly use SS-31?

A: SS-31 is widely used in mitochondrial dysfunction research, aging studies, neurodegenerative disease research, cardiovascular research, metabolic disease studies, and kidney disease research .

Q: What is the mechanism of action of SS-31?

A: SS-31 binds with high affinity to cardiolipin in the inner mitochondrial membrane, protecting it from oxidation . This preserves the structural integrity of electron transport chain complexes, reduces ROS production, and restores ATP synthesis capacity .

Q: Do you ship SS-31 to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship SS-31 Peptide to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays.

Q: What documentation do you provide with SS-31 orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Do you offer bulk quantities of SS-31 for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs.

Advance Your Research with SS-31 Peptide

eupeptidelap.co.uk is your trusted source for SS-31 Peptide, the premium choice for researchers investigating mitochondrial function, oxidative stress, and cellular bioenergetics. With over a decade of research establishing its role as a mitochondrial-targeted peptide with a thousand-fold accumulation in mitochondria, SS-31 represents a sophisticated tool for exploring the complex biology of mitochondrial health and disease. ...........................................

Whether you are exploring mitochondrial dysfunction mechanisms, designing aging studies, investigating neurodegenerative disease pathways, or researching cardiometabolic function, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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