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SLU-PP-332: The Advanced ERR Agonist for Next-Generation Metabolic Research

Buy SLU-PP-332 Peptide EU & UK, eupeptidelap.co.uk is proud to present SLU-PP-332 Peptide, a premium research-grade small molecule compound manufactured to the highest analytical standards. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with SLU-PP-332 for sale that delivers exceptional purity, consistency, and documented quality for advanced studies in metabolic regulation, exercise physiology, and mitochondrial biogenesis. Buy SLU-PP-332 Peptide EU & UK

SLU-PP-332 is a synthetic small molecule agonist of the estrogen-related receptors (ERRs), a family of nuclear receptors that play a fundamental role in regulating cellular energy metabolism . Discovered through a structure-based drug design approach, SLU-PP-332 has emerged as one of the most promising research compounds for studying metabolic pathways involved in endurance, energy expenditure, and muscle adaptation .

SLU-PP-332 functions by selectively activating all three estrogen-related receptor isoforms: ERRα, ERRβ, and ERRγ . These receptors are master regulators of metabolic gene expression, controlling pathways involved in:

Mitochondrial biogenesis and oxidative phosphorylation
Fatty acid oxidation and lipid metabolism
Glucose homeostasis and insulin sensitivity
Exercise adaptation and muscle fiber remodeling

A landmark study published in Science demonstrated that SLU-PP-332 treatment in obese mice significantly increased energy expenditure, enhanced fatty acid oxidation, and prevented weight gain . The compound has been shown to increase exercise capacity in animal models without the need for physical training, establishing it as a powerful tool for investigating exercise mimetic pathways .

For researchers seeking to buy peptide online EU for investigations into metabolic disorders, exercise physiology, or mitochondrial function, eupeptidelap.co.uk offers this premium research compound with comprehensive documentation, including Certificates of Analysis and batch-specific purity data. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research continues without interruption.

The Scientific Foundation of SLU-PP-332 Research

Discovery and Development

SLU-PP-332 was identified through a structure-based drug design campaign targeting the estrogen-related receptors (ERRs), a family of orphan nuclear receptors . Unlike traditional nuclear receptors that require specific ligands for activation, ERRs were initially considered “orphan” receptors with no known endogenous ligands. The development of synthetic agonists like SLU-PP-332 has enabled researchers to probe the functional roles of these receptors in metabolic regulation .

Mechanism of Action: Estrogen-Related Receptor Activation

SLU-PP-332 exerts its effects through selective activation of ERRα, ERRβ, and ERRγ . These receptors are constitutively active and function as master transcriptional regulators of genes involved in cellular energy metabolism.

ERRα (Estrogen-Related Receptor Alpha): The most extensively studied ERR isoform, ERRα is highly expressed in tissues with high energy demands, including heart, skeletal muscle, brown adipose tissue, and kidney . ERRα regulates genes involved in:

Mitochondrial biogenesis: PGC-1α, NRF-1, NRF-2, TFAM
Oxidative phosphorylation: Components of electron transport chain complexes I-V
Fatty acid oxidation: CPT1β, MCAD, LCAD, VLCAD
TCA cycle enzymes: SDH, IDH, MDH
Antioxidant defense: SOD2, catalase, GPX

ERRβ and ERRγ: These isoforms share significant sequence homology with ERRα and regulate overlapping but distinct sets of metabolic genes . ERRγ is particularly important in pancreatic β-cells and skeletal muscle, where it influences insulin secretion and glucose uptake .

SLU-PP-332 Selectivity Profile

SLU-PP-332 demonstrates high selectivity for ERR family receptors over other nuclear receptors. Key selectivity characteristics include:

Receptor	Activation by SLU-PP-332
ERRα	Potent agonist (EC₅₀ ~ 20-50 nM)
ERRβ	Potent agonist
ERRγ	Potent agonist
ERα (Estrogen Receptor α)	No significant activation
ERβ (Estrogen Receptor β)	No significant activation
PPARα	No significant activation
PPARγ	No significant activation

This selectivity profile makes SLU-PP-332 a valuable tool for dissecting ERR-specific effects from other nuclear receptor pathways .

Key Research Applications

Exercise Mimetic and Endurance Research

SLU-PP-332 has garnered significant attention as an exercise mimetic—a compound capable of inducing the beneficial effects of exercise without physical training . This property makes it invaluable for studying the molecular pathways underlying exercise adaptation.

Key findings from preclinical studies include:

Increased Running Endurance: SLU-PP-332 treatment in mice resulted in significantly increased running distance and time to exhaustion compared to controls
Enhanced Oxidative Metabolism: Treated animals showed increased fatty acid oxidation and improved metabolic flexibility
Muscle Fiber Remodeling: The compound induced a shift toward oxidative muscle fibers, characteristic of endurance training
Mitochondrial Biogenesis: SLU-PP-332 increased mitochondrial density and function in skeletal muscle

Metabolic Disease Research

SLU-PP-332 has demonstrated significant effects in models of obesity and metabolic syndrome:

Weight Reduction: In diet-induced obese mice, SLU-PP-332 treatment significantly reduced body weight gain and fat mass
Improved Glucose Homeostasis: The compound improved insulin sensitivity and glucose tolerance
Enhanced Energy Expenditure: Treated animals showed increased whole-body energy expenditure and thermogenesis
Hepatic Steatosis Reduction: SLU-PP-332 reduced liver fat accumulation in obese models

Mitochondrial Function Studies

As a master regulator of mitochondrial biogenesis and function, SLU-PP-332 is widely used in mitochondrial research:

Mitochondrial Biogenesis: Investigate PGC-1α-dependent and independent pathways of mitochondrial formation
Oxidative Phosphorylation: Study regulation of electron transport chain components
Mitochondrial Dynamics: Examine effects on mitochondrial fusion, fission, and mitophagy
Mitochondrial Disease Models: Explore potential therapeutic applications for mitochondrial disorders

Cardiovascular Research

ERRα is highly expressed in cardiac tissue, where it regulates energy metabolism and contractile function. SLU-PP-332 is used to study:

Cardiac Metabolism: Investigate substrate utilization (fatty acids vs. glucose) in heart tissue
Cardiac Hypertrophy: Explore ERR signaling in pathological cardiac remodeling
Ischemia-Reperfusion Injury: Study metabolic adaptations during ischemic stress

Skeletal Muscle Research

SLU-PP-332 is extensively used in muscle biology research:

Fiber Type Specification: Investigate molecular mechanisms controlling slow-twitch vs. fast-twitch fiber determination
Muscle Wasting: Explore therapeutic approaches for sarcopenia and cachexia
Metabolic Flexibility: Study substrate switching between glucose and fatty acids in muscle tissue

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

eupeptidelap.co.uk sources SLU-PP-332 from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Research-Use Only (RUO) Labeling: Full compliance with research compound regulations

Chemical and Product Specifications

Specification	Detail
Product Name	SLU-PP-332 Peptide (ERR Agonist)
CAS Number	2766700-43-8
Molecular Formula	C₂₅H₂₇ClN₄O₄
Molecular Weight	482.96 g/mol
Purity	≥99% (HPLC verified)
Appearance	White to off-white lyophilized powder
Form	Lyophilized powder
Solubility	Soluble in DMSO (≥10 mg/mL), limited water solubility
Target Receptors	ERRα, ERRβ, ERRγ
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C for short-term; aliquot and store at -20°C for longer storage
Shelf Life	24 months from date of manufacture (lyophilized)
Intended Use	Research and laboratory use only
Documentation	Certificate of Analysis provided with each batch

Stability and Handling Guidelines

Lyophilized Powder Storage: Store lyophilized SLU-PP-332 powder at -20°C in a dry, dark environment, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstitution Protocol:

Allow vial and solvent to reach ambient temperature before opening to prevent condensation
Reconstitute using DMSO for stock solutions (≥10 mg/mL). For aqueous solutions, prepare in DMSO first, then dilute with appropriate buffer
Inject solvent slowly down the inside wall of the vial to minimize foaming
Gently swirl or roll the vial until fully dissolved—do not shake vigorously
Label the vial with the date of reconstitution
Refrigerate immediately at 2-8°C

Reconstituted Solution Storage: For short-term use, store at 2-8°C. For longer-term storage, aliquot into single-use portions and store at -20°C . Avoid repeated freeze-thaw cycles.

Protection from Light and Moisture:

Store in original packaging protected from light
Keep vials tightly sealed when not in use
Allow refrigerated vials to reach room temperature before opening to prevent condensation

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity with lot-specific COAs
Well-Characterized Mechanism: Potent and selective ERRα, ERRβ, and ERRγ agonist
Exercise Mimetic Properties: Induces endurance benefits without physical training in animal models
Metabolic Research: Enhances energy expenditure, fatty acid oxidation, and mitochondrial biogenesis
Obesity Research: Reduces body weight and fat mass in diet-induced obesity models
Glucose Homeostasis: Improves insulin sensitivity and glucose tolerance
Mitochondrial Function: Potent inducer of mitochondrial biogenesis through PGC-1α pathways
Skeletal Muscle Studies: Promotes oxidative fiber type specification and metabolic flexibility
Cardiovascular Research: Regulates cardiac metabolism and energy homeostasis
Selective ERR Agonist: No significant off-target activity at estrogen receptors or PPARs
In Vivo Active: Demonstrated efficacy in preclinical animal models
Well-Characterized: Published in high-impact journals including Science
Stable Formulation: 24-month shelf life under proper storage conditions
Comprehensive Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is SLU-PP-332 and how does it work?

A: SLU-PP-332 is a synthetic small molecule agonist of the estrogen-related receptors (ERRα, ERRβ, and ERRγ) . It activates these nuclear receptors, which are master regulators of genes involved in mitochondrial biogenesis, fatty acid oxidation, and energy metabolism . In animal models, SLU-PP-332 has been shown to increase endurance and prevent weight gain in obese mice .

Q: What purity level can I expect when I buy SLU-PP-332 from eupeptidelap.co.uk?

A: All SLU-PP-332 from eupeptidelap.co.uk is tested to ≥99% purity by HPLC, with Certificates of Analysis provided with every order . Each batch is individually analyzed, ensuring you receive material suitable for rigorous research applications.

Q: What is the molecular weight and CAS number of SLU-PP-332?

A: SLU-PP-332 has a molecular weight of 482.96 g/mol and CAS number 2766700-43-8 . Its molecular formula is C₂₅H₂₇ClN₄O₄ .

Q: How should I store SLU-PP-332 for long-term stability?

A: Store lyophilized SLU-PP-332 powder at -20°C, protected from light and moisture . Under proper storage conditions, the powder maintains stability for up to 24 months. For short-term use, store reconstituted solution at 2-8°C; for longer-term storage, aliquot and store at -20°C .

Q: What is the solubility of SLU-PP-332?

A: SLU-PP-332 is soluble in DMSO at ≥10 mg/mL . It has limited water solubility; for aqueous applications, prepare stock solutions in DMSO and dilute with appropriate buffer .

Q: What research areas commonly use SLU-PP-332?

A: SLU-PP-332 is widely used in exercise mimetic and endurance research, metabolic disease studies, mitochondrial function research, cardiovascular research, and skeletal muscle biology studies .

Q: What is the mechanism of action of SLU-PP-332?

A: SLU-PP-332 is a selective agonist of ERRα, ERRβ, and ERRγ, with no significant activity at estrogen receptors or PPARs . Activation of these receptors induces expression of genes involved in oxidative metabolism, mitochondrial biogenesis, and fatty acid oxidation .

Q: Is SLU-PP-332 legal to purchase for research in the UK and EU?

A: SLU-PP-332 is an investigational compound not approved for human use by the MHRA in the UK or the EMA in the EU . It is sold strictly for research purposes only. The sale of unlicensed compounds under “research use only” labeling is permissible for legitimate research purposes when supplied to qualified buyers such as laboratories and research facilities .

Q: Do you ship SLU-PP-332 to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship SLU-PP-332 to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays. All shipments use protective packaging to maintain compound integrity during transit.

Q: What documentation do you provide with SLU-PP-332 orders?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data . Additional documentation, including HPLC chromatograms and mass spectrometry data, is available upon request for researchers requiring comprehensive analytical verification.

Q: Has SLU-PP-332 been studied in animal models?

A: Yes. A landmark study published in Science demonstrated that SLU-PP-332 treatment in obese mice significantly increased energy expenditure, enhanced fatty acid oxidation, and prevented weight gain . The compound also increased exercise capacity in animal models without physical training .

Q: Do you offer bulk quantities of SLU-PP-332 for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements for ongoing research programs. ...........................................

Advance Your Research with SLU-PP-332 Peptide

eupeptidelap.co.uk is your trusted source for SLU-PP-332 Peptide, the premium choice for researchers investigating exercise mimetic pathways, metabolic disorders, and mitochondrial function. With over a decade of research since its discovery, SLU-PP-332 has emerged as one of the most potent and selective ERR agonists available for the research community .

Whether you are exploring exercise mimetic mechanisms, designing metabolic studies, investigating mitochondrial biogenesis, or researching cardiovascular metabolism, our rigorously tested compound provides the quality and consistency your work demands. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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selectivity screening

SLU-PP-332 Peptide