Premium MT-2 Starter Kit with 30mg Lyophilized Peptide, Bacteriostatic Water & Insulin Syringes | ≥99% Purity | 48-Hour Delivery Across EU & UK

Melanotan II Starter Kit: The Complete Research Package for Melanocortin Receptor Studies

ukpeptidesshop.uk is proud to present the Melanotan 2 (MT-2) STARTER KIT UK, a comprehensive research package containing everything needed for advanced melanocortin receptor investigations. As a trusted peptide vendor uk and leading EU peptide supplier, we provide researchers across Europe with this complete research kit for sale that delivers exceptional purity, consistency, and documented quality for studies in melanogenesis, receptor pharmacology, and metabolic regulation .

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH), originally developed at the University of Arizona in the 1980s to increase melanin formation and protect the skin from harmful UV radiation . The peptide has the cyclic structure Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH2, with the crucial D-Phe-7 substitution that contributes to its superagonist properties and enhanced potency compared to earlier melanotropic peptides . NMR spectroscopy and molecular modeling suggest a “reverse-turn” conformation at its active site, which underpins its activity on melanocortin receptors .

Melanotan II acts as a non-selective agonist of melanocortin receptors, binding to MC1R (primarily responsible for melanogenesis), MC3R, and MC4R . Its propensity to improve skin pigmentation has made it popular in cosmetic research, while its modulation of other melanocortin receptors opens doors for studies in sexual function and appetite regulation . This “pharmacologically noisy” molecule delivers potent effects across multiple receptor subtypes, making it a valuable but complex tool for receptor pharmacology research .

This complete starter kit includes:

30mg Melanotan II (lyophilized powder, ≥99% purity)
30mL Bacteriostatic Water (sterile 0.9% benzyl alcohol solution)
30 Insulin Syringes (U-100, 0.3mL/30-unit for precision dosing)
Batch-specific Certificate of Analysis for the peptide
Full technical documentation

For researchers seeking to buy peptide online EU for investigations into melanocortin receptor signaling, melanogenesis pathways, or metabolic regulation, ukpeptidesshop.uk offers this premium research kit with comprehensive documentation and all necessary components in one convenient package. Whether your laboratory is based in London, Berlin, Paris, or anywhere in the European Union, our guaranteed 48 hour delivery peptide service ensures your research supplies arrive when you need them.

The Scientific Foundation of Melanotan II Research

Discovery and Development

Melanotan II was created as a counterpart to the body’s naturally occurring hormone, alpha-melanocyte-stimulating hormone (α-MSH), and was designed to enhance the body’s natural tanning process by activating melanocortin receptors . Early research focused on its capacity to increase melanin formation and provide protection against sun-induced skin damage . However, during clinical investigations, researchers discovered that Melanotan II affected other physiological functions beyond pigmentation, including appetite regulation and sexual arousal, leading to potential applications in obesity and erectile dysfunction research .

Mechanism of Action: Melanocortin Receptor Activation

Melanotan II works by mimicking the effects of α-MSH on the melanocortin receptor system, which comprises five receptor subtypes (MC1R to MC5R) that control a range of physiological functions including pigmentation, appetite, and sexual function .

MC1R Activation and Melanogenesis: Of these receptors, MC1R is principally responsible for regulating melanogenesis—the process that produces skin pigmentation. When Melanotan II binds to MC1R on melanocytes, it triggers a signaling cascade that pushes the melanocyte toward producing more eumelanin (brown-black pigment) over pheomelanin (red-yellow pigment) and increases overall melanin content . This results in a darker, more UV-resistant skin phenotype over time—similar to how some individuals naturally tan more deeply due to their MC1R variants, but induced pharmacologically .

MC3R and MC4R Activation: Melanotan II’s broader receptor affinity extends its pharmacology well beyond the skin. By acting on MC3R and MC4R in the central nervous system, it modulates appetite, energy homeostasis, and sexual function . This explains why researchers observe effects such as appetite suppression, changes in libido, and erectile responses in experimental models . The cyclic design of Melanotan II improves stability and potency, so lower doses still exert strong effects across multiple receptor systems .

Pharmacokinetic Profile

Melanotan II is typically administered subcutaneously, where it is absorbed into the bloodstream, distributed through the body, and then cleared by enzymatic degradation and renal excretion . Available data from early-stage studies suggest a plasma half-life on the order of about 30 minutes to a couple of hours, with many sources clustering around approximately 1 hour . This short plasma half-life is typical for unmodified peptides that are not pegylated, lipidated, or otherwise engineered for extended circulation.

However, a short plasma half-life does not mean a short functional effect. Once Melanotan II binds melanocortin receptors in melanocytes and downstream signaling initiates, the biological cascade—upregulated melanin synthesis, packaging in melanosomes, and transfer to keratinocytes—continues well after the peptide level falls . This explains why a brief spike in blood levels can translate into pigmentation effects over several days or weeks.

Key Research Applications

Melanogenesis and Pigmentation Research

Melanotan II is extensively used in studies investigating skin pigmentation mechanisms and melanin synthesis pathways. Early Phase I clinical studies demonstrated that subcutaneous injections of Melanotan II produced increased pigmentation in the face, upper body, and buttock, as measured by quantitative reflectance and visual perception just one week after dosing ended . These results confirmed that MT-II has tanning activity in humans given only 5 low doses every other day by subcutaneous injection .

Research has shown that Melanotan II can induce significant changes in skin color in vivo, such as transforming the pelage color of mice from light yellow to dark brown or black upon subcutaneous administration, demonstrating its potent melanogenic efficacy . The peptide also enhances tyrosinase activity—a key enzyme in melanin synthesis—for days after initial exposure, suggesting a lasting effect at the transcriptional or translational level .

Erectile Dysfunction and Sexual Function Research

During early clinical trials, researchers observed a notable effect on sexual function. A stretching and yawning complex appeared to correlate with the onset of spontaneous, penile erections which were intermittently experienced for 1–5 hours after MT-II dosing, depending on the dose administered . This finding prompted research into the possibility of using Melanotan II to treat sexual dysfunction, particularly erectile dysfunction, where it could offer an alternative to conventional treatments .

The recommended single MT-II dose for erectile dysfunction research, based on Phase I studies, is 0.025 mg/kg/day . Studies on how Melanotan II affects sexual function have revealed that it may heighten sexual desire and improve overall sexual satisfaction, making it relevant for broader research into sexual health and dysfunction .

Appetite Regulation and Obesity Research

Melanotan II’s role in regulating appetite and energy balance represents another intriguing research application. By acting on MC4R to regulate energy balance and decrease food intake, Melanotan II has potential as a research tool for studying obesity and metabolic disorders . The peptide’s ability to affect hunger presents a novel avenue for investigating metabolic pathways and potential therapeutic interventions.

Photoprotection and Skin Cancer Research

Melanotan II was initially investigated for its potential to prevent skin cancer by increasing melanin formation and providing protection against damaging UV radiation . This is especially relevant for fair-skinned individuals who are more susceptible to melanoma. By boosting the body’s natural defenses against UV radiation through increased melanin production, Melanotan II may help reduce the chance of sunburn and subsequent skin damage . Research in this area continues to explore the peptide’s potential role in photoprotection strategies.

Melanocortin Receptor Pharmacology

Melanotan II serves as a valuable research tool for studying melanocortin receptor pharmacology and signaling pathways. Its non-selective agonist activity across MC1R, MC3R, and MC4R allows researchers to investigate receptor interactions, signal transduction mechanisms, and downstream effects in various tissue types .

Starter Kit Components and Specifications

Component	Quantity	Description	Purpose
Melanotan II (MT-2)	1 vial	30mg lyophilized powder, ≥99% purity	Active research compound
Bacteriostatic Water	1 vial	30mL sterile 0.9% benzyl alcohol solution	Sterile diluent for reconstitution
Insulin Syringes	30 units	U-100, 0.3mL (30-unit) with 31G × 8mm needles	Precision dosing and administration
Certificate of Analysis	1 copy	Batch-specific purity documentation	Quality assurance

Melanotan II Specifications

Specification	Detail
Product Name	Melanotan II (MT-2, Melanotan-2)
CAS Number	121062-08-6
Molecular Formula	C50H69N15O9 (cyclic heptapeptide)
Molecular Weight	~1024 Da
Sequence	Ac-Nle4-Asp5-His6-D-Phe7-Arg8-Trp9-Lys10 α-MSH4-10-NH2
Structure	Cyclic heptapeptide with lactam bridge
Purity	≥99% (HPLC verified)
Appearance	White to off-white lyophilized powder
Target Receptors	MC1R, MC3R, MC4R (melanocortin receptors)
Storage (Lyophilized)	-20°C; protect from light and moisture
Storage (Reconstituted)	2-8°C; use within 4 weeks; do not freeze

Bacteriostatic Water Specifications

Specification	Detail
Composition	99.1% WFI Water, 0.9% Benzyl Alcohol
Preservative	0.9% (9 mg/mL) benzyl alcohol
Fill Volume	30 mL multi-dose vial
pH Range	4.5–7.0
Sterility	Sterile; Non-Pyrogenic
In-Use Period	Up to 28 days after first puncture

Insulin Syringe Specifications

Specification	Detail
Volume	0.3 mL (30 units)
Needle Gauge	31 gauge
Needle Length	8 mm (5/16 inch)
Graduations	1-unit increments for precision dosing
Sterility	Individually packaged, sterile
Application	Subcutaneous administration

Reconstitution and Handling Protocol

Step-by-Step Reconstitution Guide

Allow vials to reach ambient temperature before opening to prevent condensation

2 Calculate desired concentration:

For 1 mg/mL concentration: Reconstitute 30 mg with 30 mL bacteriostatic water
For 2 mg/mL concentration: Reconstitute 30 mg with 15 mL bacteriostatic water
For standard research protocol: Reconstitute 30 mg with 3 mL bacteriostatic water (10 mg/mL) for smaller injection volumes

Disinfect vial tops of both the MT-2 vial and bacteriostatic water vial with alcohol swabs
Draw air into the syringe equal to the amount of bacteriostatic water to be used, then inject this air into the water vial to avoid pressure build-up
Withdraw the prescribed amount of bacteriostatic water
Inject slowly into the MT-2 vial, allowing it to run down the inside wall to minimize bubbling and foaming
Gently swirl the vial (do not shake) until the powder fully dissolves—shaking can damage peptide bonds
Label the vial with the date of reconstitution and concentration
Refrigerate immediately at 2-8°C

Storage Guidelines

Lyophilized MT-2: Store at -20°C or below in a dry, dark environment, protected from light and moisture. Under proper storage conditions, the powder maintains stability for up to 24 months from the date of manufacture.

Reconstituted MT-2: Store at 2-8°C (refrigeration) and protect from light. Use within 4 weeks (28 days) for optimal potency and safety. Do not freeze reconstituted solution. Discard any unused solution after this period.

Bacteriostatic Water: Store unopened vials at controlled room temperature (20–25°C). After opening, use within 28 days per USP guidelines.

Protection from Light: Keep all components in original packaging protected from light. Amber vials provide additional protection for light-sensitive peptides.

Quality Assurance: Setting the Standard for Research Compounds

Manufacturing Excellence

ukpeptidesshop.uk sources the Melanotan 2 Starter Kit from certified GMP facilities with rigorous quality control protocols:

HPLC Purity Analysis: ≥99% purity verified by high-performance liquid chromatography
Mass Spectrometry Verification: Molecular weight confirmation via LC-HRMS
Batch-Specific Certificates of Analysis: Complete documentation for each production run
Sterile Manufacturing: Produced under stringent conditions in ISO-certified laboratories
Third-Party Lab Testing: Independent verification of purity and potency

Key Benefits

Premium Quality Manufacturing: GMP-certified production, ≥99% HPLC-verified purity
Complete Starter Kit: Everything needed for research in one convenient package
Comprehensive Research Tool: Enables studies in melanogenesis, sexual function, appetite regulation, and receptor pharmacology
Potent Melanotropic Activity: Demonstrated superpotent activity in vitro and in vivo
MC1R Activation: Stimulates melanin synthesis through selective MC1R binding
MC3R/MC4R Pharmacology: Broader receptor activity enables diverse research applications
Proven Efficacy: Phase I clinical studies confirmed tanning activity in humans with only 5 low doses
Rapid Receptor Binding: Short half-life (~1 hour) with prolonged biological effects
Sustained Pigmentation: Lasting melanogenic effects continue after peptide clearance
Sexual Function Research: Documented effects on erectile function and libido
Appetite Regulation Studies: MC4R-mediated effects on energy balance and food intake
Photoprotection Research: Potential applications in UV protection and skin cancer prevention
Receptor Pharmacology: Valuable tool for melanocortin receptor signaling studies
Tyrosinase Activation: Enhances key enzyme activity for melanin synthesis
Complete Documentation: Certificates of Analysis with batch-specific purity data
48-Hour EU & UK Delivery: Rapid shipping to research facilities across Europe
Batch Consistency: Rigorous quality control ensures lot-to-lot reproducibility
EU Sourced: Available from within the European Union

Frequently Asked Questions

Q: What is included in the Melanotan 2 Starter Kit?

A: The Melanotan 2 (MT-2) STARTER KIT UK includes one vial containing 30mg of high-purity Melanotan II lyophilized powder (≥99% purity), one 30mL vial of bacteriostatic water (sterile 0.9% benzyl alcohol solution), and 30 sterile insulin syringes (U-100, 0.3mL with 31G needles) .

Q: What is Melanotan II and how does it work?

A: Melanotan II is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH) . It activates melanocortin receptors (MC1R, MC3R, MC4R), stimulating melanin production, affecting appetite regulation, and influencing sexual function .

Q: What purity level can I expect when I buy Melanotan II from ukpeptidesshop.uk?

A: All Melanotan II from ukpeptidesshop.uk is tested to ≥99% purity by HPLC. Each batch is individually analyzed, and Certificates of Analysis are provided with every order.

Q: How should I reconstitute Melanotan II for research use?

A: Reconstitute using the provided bacteriostatic water. Allow vials to reach room temperature, disinfect vial tops, withdraw desired amount of bacteriostatic water, inject slowly into the MT-2 vial, and gently swirl until dissolved. Do not shake .

Q: How should I store the kit components?

A: Store lyophilized MT-2 at -20°C or below, protected from light and moisture. Store bacteriostatic water at room temperature (20-25°C). After reconstitution, refrigerate MT-2 at 2-8°C and use within 4 weeks. Do not freeze reconstituted solution .

Q: What is the recommended research dose for Melanotan II?

A: Based on Phase I clinical studies, the recommended single dose for research is 0.025 mg/kg/day . For a 70kg subject, this would be approximately 1.75 mg per dose. Always determine appropriate dosing based on specific research protocols.

Q: What research areas commonly use Melanotan II?

A: Melanotan II is widely used in melanogenesis and pigmentation research, erectile dysfunction and sexual function studies, appetite regulation and obesity research, photoprotection and skin cancer prevention research, and melanocortin receptor pharmacology studies .

Q: What is the half-life of Melanotan II?

A: Available data suggest a plasma half-life on the order of about 30 minutes to a couple of hours, with most sources clustering around approximately 1 hour . Despite this short plasma half-life, biological effects persist much longer due to downstream melanogenic cascades.

Q: Do you ship this starter kit to EU countries?

A: Yes. As a dedicated EU peptide supplier, we ship the Melanotan 2 Starter Kit to all European Union member states with our guaranteed 48 hour delivery peptide service. Our EU fulfilment centre ensures rapid delivery without customs delays.

Q: What documentation do you provide with this kit?

A: Every order includes a Certificate of Analysis (COA) with batch-specific purity data for the Melanotan II peptide. Additional documentation is available upon request.

Q: Has Melanotan II been studied in clinical trials?

A: Yes. Phase I clinical studies were conducted with Melanotan II in normal male volunteers, demonstrating its tanning activity and effects on sexual function . The recommended single dose from these studies is 0.025 mg/kg/day.

Q: What are the observed side effects in research settings?

A: In clinical studies, observed effects included mild nausea, fatigue, somnolence at higher doses, and a stretching and yawning complex associated with spontaneous penile erections . Nausea, stomach cramps, decreased appetite, flushing, and darkened skin have also been reported .

Q: Do you offer bulk quantities for institutional research?

A: Yes. We accommodate bulk orders for research institutions. Contact our team at sales@eupeptidelap.co.uk for volume pricing, custom requirements, and supply agreements.

Q: What is the legal status of Melanotan II for research in the UK?

A: Melanotan II is not a licensed medicine in the UK and is not approved for human consumption . It is sold strictly for research purposes only. All products from ukpeptidesshop.uk are intended for research and laboratory use only, not for human consumption.

Advance Your Research with the Melanotan 2 Starter Kit

ukpeptidesshop.uk is your trusted source for the Melanotan 2 (MT-2) STARTER KIT UK, the premium choice for researchers investigating melanocortin receptor signaling, melanogenesis pathways, and metabolic regulation. With well-characterized mechanisms across multiple receptor subtypes and extensive peer-reviewed literature supporting its research applications, Melanotan II represents a sophisticated tool for exploring the complex biology of the melanocortin system. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

This complete starter kit provides everything needed for research, eliminating the need to source components separately. The 30mg vial offers substantial material for extended studies, while the included bacteriostatic water and insulin syringes ensure proper reconstitution and administration from the start. ...........................................

Whether you are exploring melanogenesis pathways, designing sexual function studies, investigating appetite regulation, or researching photoprotection mechanisms, our rigorously tested kit provides the quality and consistency your work demands.

Order today and experience the ukpeptidesshop.uk difference – premium quality, rapid 48-hour delivery across the EU and UK, and expert support for the European research community.

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